Projects

Research directions

• Study on morphofunctional specificities and mechanisms for differentiation of stem cells;
• Development of cell transplantants and tissue-engineered designs for recovery of structure and functions of damaged organs and tissues;
• Development of technologies for production of human’s induced pluripotent stem cell and study their potential usage in regenerative medicine and cells therapy.

Innovative developments

• Cell medicine based on human allogenic fibroblasts for thermal injuries and continuously non-healing wounds treatment.

Core publications

Bulashev A., Mukhlis Sh., Manat E., Mukhambetova A., Berdikulov M., Karibayev T., Bilyalov Ye, Kaukabayeva G., Eskendirova S.
Diagnostic Usefulness of Combined Periplasmic Proteins in Bovine Brucellosis. Int J Vet Sci. – 2025. Vol.14(2): PP.316-324. https://doi.org/10.47278/journal.ijvs/2024.251

Dairov A, Sekenova A, Alimbek S, Nurkina A, Shakhatbayev M, Kumasheva V, Kuanysh S, Adish Z, Issabekova A, Ogay V.
Psoriasis: The Versatility of Mesenchymal Stem Cell and Exosome Therapies. Biomolecules. – 2024. Vol.14(11):1351. doi:10.3390/biom14111351

Kudaibergen G, Mukhlis S, Mukhambetova A, Issabekova A, Sekenova A, Sarsenova M, Temirzhan A, Baidarbekov M, Umbayev B, Ogay V.
Repair of Rat Calvarial Critical-Sized Defects Using Heparin-Conjugated Fibrin Hydrogel Containing BMP-2 and Adipose-Derived Pericytes. Bioengineering. – 2024. Vol. 11(5):437. doi:10.3390/bioengineering11050437

Issabekova A, Kudaibergen G, Sekenova A, Dairov A, Sarsenova M, Mukhlis S, Temirzhan A, Baidarbekov M, Eskendirova S, Ogay V.
The Therapeutic Potential of Pericytes in Bone Tissue Regeneration. Biomedicines. – 2024. Vol.12(1):21. doi:10.3390/biomedicines12010021

Sekenova A, Li Y, Issabekova A, Saparov A, Ogay V.
TNF-α Preconditioning Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in an Experimental Model of Atherosclerosis. Cells. – 2023. Vol. 12(18):2262. doi:10.3390/cells12182262

Kanayev D, Abilmazhenova D, Akhmetollayev I, Sekenova A, Ogay V, Kulyyassov A.
Detection of Recombinant Proteins SOX2 and OCT4 Interacting in HEK293T Cells Using Real-Time Quantitative PCR. Life. – 2023. Vol.13(1):107. doi: 10.3390/life13010107

Bulashev A and Eskendirova S.
Brucellosis detection and the role of Brucella spp. cell wall proteins. Veterinary World. – 2023. Vol.16(7): 1390-1399. doi: 10.14202/vetworld.2023.1390-1399

Kudaibergen, G., Akhmetkarimova, Z., Yildirim, E. et al.
Thiol-ene clickable gelatin–hyaluronic acid cryogels. The Journal of Materials Science. – 2023. №58. PP.10821–10831. doi: 10.1007/s10853-023-08693-z

Sarsenova M, Raimagambetov Y, Issabekova A, Karzhauov M, Kudaibergen G, Akhmetkarimova Z, Batpen A, Ramankulov Y, Ogay V.
Regeneration of Osteochondral Defects by Combined Delivery of Synovium-Derived Mesenchymal Stem Cells, TGF-β1 and BMP-4 in Heparin-Conjugated Fibrin Hydrogel. Polymers (Basel). – 2022; Vol.14(24):5343. doi: 10.3390/polym14245343

Sarsenova M, Kim Y, Raziyeva K, Kazybay B, Ogay V, Saparov A.
Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells. Front Immunol. – 2022. 13:1010399. doi: 10.3389/fimmu.2022.1010399

Dairov A, Issabekova A, Sarsenova M, Sekenova A, Shakhatbayev M, Alimbek S, Kudaibergen G, Nurkina A, Akhmetollayev I, Kang K.S., Ogay V.
Study of the Therapeutic Effect of Cytokine-Preconditioned Mesenchymal Stem Cells and Their Exosomes in a Mouse Model of Psoriasis. Biology (Basel). – 2025. Vol.14(8):1033. – doi: 10.3390/biology14081033.

Dairov A, Issabekova A, Ogay V.
Mesenchymal Stem Cell-derived Exosomes in the Treatment of Skin and Subcutaneous Tissue Diseases: A Review. Curr Stem Cell Res Ther. – 2025. Jul 11. – doi: 10.2174/011574888X393159250704132425.