Проекты

Направления исследований

• Разработка клеточных и тканеинженерных препаратов для лечения ран, дефектов хряща и кости;
• Разработка инновационных методов и подходов клеточной терапии аутоиммунных заболеваний с использованием стволовых мезенхимальных клеток;
• Разработка «умных» и функционализированных биоматериалов и полимеров для тканевой инженерии и регенеративной медицины.

Инновационные разработки

• Клеточный препарат на основе аллогенных фибробластов человека для лечения ожогов и длительно незаживающих ран.

Основные публикации

Sarsenova M, Kim Y, Raziyeva K, Kazybay B, Ogay V, Saparov A.
Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells. Front Immunol. 2022;13:1010399. doi: 10.3389/fimmu.2022.1010399.

Kudaibergen G, Zhunussova M, Mun EA, Ramankulov Y, Ogay V.
Macroporous Cell-Laden Gelatin/Hyaluronic Acid/Chondroitin Sulfate Cryogels for Engineered Tissue Constructs. Gels. 2022; 8(9):590. doi: 10.3390/gels8090590.

Sarsenova M, Raimagambetov Y, Issabekova A, Karzhauov M, Kudaibergen G, Akhmetkarimova Z, Batpen A, Ramankulov Y, Ogay V.
Regeneration of Osteochondral Defects by Combined Delivery of Synovium-Derived Mesenchymal Stem Cells, TGF-β1 and BMP-4 in Heparin-Conjugated Fibrin Hydrogel. Polymers (Basel). 2022; 14(24):5343. doi: 10.3390/polym14245343.

Tuleubayev B, Ogay V, Anapiya B, Zhylkibayev A, Saginova D, Koshanova A, Kurmangaliyev YD, Tezekbayev K, Bikonurov N, Abugaliyev K.
Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial. Medicina (Kaunas). 2022; 58(6):819. doi: 10.3390/medicina58060819.

Zhubanova G.S., Mukhambetova А.E., Karzhauov M.R., Issabekova A.S., Raimagambetov E.K., Ogay V.B.
The effect of combinations of growth factors and hyaluronic acid on the proliferation and chondrogenic differentiation of human synovium derived mesenchymal stem cells // Eurasian Journal of Applied Biotechnology. - 2022. - № 2 – P. 41-50.

Toktarov T., Saginov B., Raimagambetov Y., Balbossynov B., Korganbekova G., Urazayev M., Issabekova A., Zhubanova G., Kaukabayeva G., Sekenova A., Kudaibergen G., Akhmetkarimova Zh., Eskendirova S., Ramankulov Y., Bekarissov O., Batpen A., Ogay V.
Heparin-conjugated fibrin hydrogel with chondroinductive growth factors and human Synovium-derived mesenchymal stem cells for the treatment of articular cartilage defects: Evaluation of clinical safety. International Journal of Biomedicine. 2022, 12(4):539–547. doi: 10.21103/Article12(4)_OA3

Sarsenova M, Mukhambetova A, Saginov B, Raimagambetov Y, Ogay V.
Synovium-Derived Mesenchymal Stem Cells in Combination with Low Molecular Weight Hyaluronic Acid for Cartilage Repair. International Journal of Biomedicine, 2022, 12(4):548–553. doi: 10.21103/Article12(4)_OA4

Kang HK, Sarsenova M, Kim DH, Kim MS, Lee JY, Sung EA, Kook MG, Kim NG, Choi SW, Ogay V, Kang KS.
Establishing a 3D In Vitro Hepatic Model Mimicking Physiologically Relevant to In Vivo State. Cells. 2021;10(5):1268. doi:10.3390/cells10051268.

Ogay V, Sekenova A, Li Y, Issabekova A, Saparov A.
The Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Atherosclerosis. Curr Stem Cell Res Ther. 2021; 16(7):897-913. doi: 10.2174/1574888X16999210128193549.

Ogay V, Kumasheva V, Li Y, Mukhlis S, Sekenova A, Olzhayev F, Tsoy A, Umbayev B, Askarova S, Shpekov A, Kaliyev A, Zhetpisbayev B, Makhambetov Y, Akshulakov S, Saparov A, Ramankulov Y.
Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-derived Pericytes. Cell Transplant. 2020; 29:963689720956956. doi: 10.1177/0963689720956956.