Assel
Issabekova
Head of laboratory, Ph.D.
Specialist in the field of cell biology and immunotherapy. Research interests: stem cells, cancer stem cells, immunotherapy, tissue engineering, cell therapy. Author of more than 30 scientific articles, 10 of them are included to the Scopus database. Owner of the h-index – 6, winner of a presidential scholarship (2005-2007), owner of the place “Best young scientist” (2016), owner of the “BOLASHAQ” scholarship within the program of “500 scientific internships” (2022-2023), owner of the “Kurmet” diploma of the Ministry of Health of the Republic of Kazakhstan (2022), badge for contribution to the development of healthcare (2024).
ORCID ID – 0000-0002-8844-2510
Scopus ID – 55820794800
Projects
Research directions
- Study on morphofunctional specificities and mechanisms for differentiation of stem cells;
- Development of cell transplantants and tissue-engineered designs for recovery of structure and functions of damaged organs and tissues;
- Development of technologies for production of human’s induced pluripotent stem cell and study their potential usage in regenerative medicine and cells therapy.
Innovative developments
- Cell medicine based on human allogenic fibroblasts for thermal injuries and continuously non-healing wounds treatment.
Core publications
Bulashev A., Mukhlis Sh., Manat E., Mukhambetova A., Berdikulov M., Karibayev T., Bilyalov Ye, Kaukabayeva G., Eskendirova S.
Diagnostic Usefulness of Combined Periplasmic Proteins in Bovine Brucellosis. Int J Vet Sci. – 2025. Vol.14(2): PP.316-324. https://doi.org/10.47278/journal.ijvs/2024.251
Dairov A, Sekenova A, Alimbek S, Nurkina A, Shakhatbayev M, Kumasheva V, Kuanysh S, Adish Z, Issabekova A, Ogay V.
Psoriasis: The Versatility of Mesenchymal Stem Cell and Exosome Therapies. Biomolecules. – 2024. Vol.14(11):1351. doi:10.3390/biom14111351
Kudaibergen G, Mukhlis S, Mukhambetova A, Issabekova A, Sekenova A, Sarsenova M, Temirzhan A, Baidarbekov M, Umbayev B, Ogay V.
Repair of Rat Calvarial Critical-Sized Defects Using Heparin-Conjugated Fibrin Hydrogel Containing BMP-2 and Adipose-Derived Pericytes. Bioengineering. – 2024. Vol. 11(5):437. doi:10.3390/bioengineering11050437
Issabekova A, Kudaibergen G, Sekenova A, Dairov A, Sarsenova M, Mukhlis S, Temirzhan A, Baidarbekov M, Eskendirova S, Ogay V.
The Therapeutic Potential of Pericytes in Bone Tissue Regeneration. Biomedicines. – 2024. Vol.12(1):21. doi:10.3390/biomedicines12010021
Sekenova A, Li Y, Issabekova A, Saparov A, Ogay V.
TNF-α Preconditioning Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in an Experimental Model of Atherosclerosis. Cells. – 2023. Vol. 12(18):2262. doi:10.3390/cells12182262
Kanayev D, Abilmazhenova D, Akhmetollayev I, Sekenova A, Ogay V, Kulyyassov A.
Detection of Recombinant Proteins SOX2 and OCT4 Interacting in HEK293T Cells Using Real-Time Quantitative PCR. Life. – 2023. Vol.13(1):107. doi: 10.3390/life13010107
Bulashev A and Eskendirova S.
Brucellosis detection and the role of Brucella spp. cell wall proteins. Veterinary World. – 2023. Vol.16(7): 1390-1399. doi: 10.14202/vetworld.2023.1390-1399
Kudaibergen, G., Akhmetkarimova, Z., Yildirim, E. et al.
Thiol-ene clickable gelatin–hyaluronic acid cryogels. The Journal of Materials Science. – 2023. №58. PP.10821–10831. doi: 10.1007/s10853-023-08693-z
Sarsenova M, Raimagambetov Y, Issabekova A, Karzhauov M, Kudaibergen G, Akhmetkarimova Z, Batpen A, Ramankulov Y, Ogay V.
Regeneration of Osteochondral Defects by Combined Delivery of Synovium-Derived Mesenchymal Stem Cells, TGF-β1 and BMP-4 in Heparin-Conjugated Fibrin Hydrogel. Polymers (Basel). – 2022; Vol.14(24):5343. doi: 10.3390/polym14245343
Sarsenova M, Kim Y, Raziyeva K, Kazybay B, Ogay V, Saparov A.
Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells. Front Immunol. – 2022. 13:1010399. doi: 10.3389/fimmu.2022.1010399