Projects

Research directions

• Mass spectrometry-based proteomics research and systems biology;
• Identification of proteomic and other biomarkers associated with socially significant and oncological diseases;
• Study of microbial evolution and mechanisms of antimicrobial resistance;
• Paleoproteomics

Innovative developments

• “Application of biotin ligase BirA and biotin acceptor peptides BAP1070 and BAP1108 for detecting protein–protein interactions in vivo using BirA/BAP1070 and BirA/BAP1108 pairs.” Eurasian Patent No. 034880
• “Method for diagnosing the risk of restenosis in the Kazakh population after coronary artery stenting.” Patent of the Republic of Kazakhstan No. 30963
• “Method for determining human blood group using real-time PCR.” Patent of the Republic of Kazakhstan No. 30241
• “Method for determining the complete mitochondrial DNA genome.” Patent of the Republic of Kazakhstan No. 25562

Core publications

Makhammajanov Z., Kabayeva A., Auganova D., Tarlykov P., Bukasov R., Turebekov D., Kanbay M., Molnar M., Kovesdy C., Syed Abidi S., Gaipov A.
Candidate protein biomarkers in chronic kidney disease: a proteomics study // Scientific Reports. ‒ 2024. ‒ Vol.14, №1. ‒ P.14014.

Akhmadi A., Yeskendir A., Dey N., Mussakhmetov A., Shatkenova Z., Kulyyassov A., Andreeva A., Utepbergenov D.
DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride // Nature Communications. ‒ 2024. ‒ Vol.15, №1.

Auganova D., Atavliyeva S., Amirgazin A., Akisheva A., Tsepke A., Tarlykov P.
Genomic Characterization of Drug-Resistant Mycobacterium tuberculosis L2/Beijing Isolates from Astana, Kazakhstan // Antibiotics. ‒ 2023. ‒ Vol.12, №10. ‒ P.1523.

Kulyyassov A., Fresnais M., Longuespée R.
Targeted liquid chromatography-tandem mass spectrometry analysis of proteins: Basic principles, applications, and perspectives // Proteomics. ‒ 2021.

Tarlykov P., Atavliyeva S., Auganova D., Akhmetollayev I., Loshakova T., Varfolomeev V., Ramankulov Y.
Mitochondrial DNA analysis of ancient sheep from Kazakhstan: evidence for early sheep introduction // Heliyon. ‒ 2021. ‒ Vol.7, №9. ‒ P.e08011.

Tarlykov P., Atavliyeva S., Alenova A., Ramankulov Y.
Memorias do Instituto Oswaldo Cruz. ‒ 2020. ‒ Vol.115, №8. ‒ P.1-6.Genomic analysis of Latin American-Mediterranean family of Mycobacterium tuberculosis clinical strains from Kazakhstan // Memorias do Instituto Oswaldo Cruz. ‒ 2020. ‒ Vol.115, №8. ‒ P.1-6.

Jurisic A., Robin C., Tarlykov P., Ogryzko V.
Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains // Nucleic Acids Research. ‒ 2018. ‒ Vol.46, №22. ‒ P.e135.

Kim E., Rich J., Karoutas A., Tarlykov P., Ogryzko V.
ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophy // Nucleic Acids Research. ‒ 2015. ‒ Vol.43, №17. ‒ P.8227-8242.

Shoaib M., Kulyyassov A., Robin C, Tarlykov P., Despas E., Kannouche P., Ramanculov E., Lipinski M., Ogryzko V.
PUB-NChIP--"in vivo biotinylation" approach to study chromatin in proximity to a protein of interest // Genome Research. ‒ 2013. ‒ Vol.23, №2. ‒ P.331-340.

Maaty W.S., Selvig K., Ryder S. Tarlykov P., Hilmer J., Bothner B.
Proteomic Analysis of Sulfolobus solfataricus during Sulfolobus Turreted Icosahedral Virus Infection // Journal of Proteome Research. ‒ 2012. ‒ Vol.11, №2. ‒ P.1420-1432.