Role of the immune system in cardiac tissue damage and repair following myocardial infarction

Inflammation research (2017)
Saparov A, Ogay V, Nurgozhin T, Chen WCW, Mansurov N, Issabekova A, Zhakupova J.
First online: 09 June 2017
DOI: 10.1007/s00011-017-1060-4



The immune system plays a crucial role in the initiation, development, and resolution of inflammation following myocardial infarction (MI). The lack of oxygen and nutrients causes the death of cardiomyocytes and leads to the exposure of danger-associated molecular patterns that are recognized by the immune system to initiate inflammation.


At the initial stage of post-MI inflammation, the immune system further damages cardiac tissue to clear cell debris. The excessive production of reactive oxygen species (ROS) by immune cells and the inability of the anti-oxidant system to neutralize ROS cause oxidative stress that further aggravates inflammation. On the other hand, the cells of both innate and adaptive immune system and their secreted factors are critically instrumental in the very dynamic and complex processes of regulating inflammation and mediating cardiac repair.


It is important to decipher the balance between detrimental and beneficial effects of the immune system in MI. This enables us to identify better therapeutic targets for reducing the infarct size, sustaining the cardiac function, and minimizing the likelihood of heart failure. This review discusses the role of both innate and adaptive immune systems in cardiac tissue damage and repair in experimental models of MI.


Immune system; Inflammation; Myocardial infarction; Tissue damage; Tissue repair


О нас

Республиканское государственное предприятие «Национальный центр биотехнологии» Комитета науки Министерства образования и науки Республики Казахстан – ведущий биологический научный центр страны, реализующий государственную политику поддержки и развития биотехнологической отрасли - создан Указом Президента Республики Казахстан в 1993 г.

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