National Scientific Shared Laboratory of Biotechnology

Head of the Laboratory

 

ZHOLDYBAYEVA ELENA

 
Candidate of biological sciences 

 

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+7(7172) 70 75 16

 
 

A specialist in the field of molecular biology of viruses, population genetics and genomic research. Author of over 40 research articles, has 5 certificates of authorship for the development of diagnostic test kits based on PCR. L. Orbeli scholarship recipient, Russia (2001). Awarded with a Diploma of MES for contributions to the science of Kazakhstan (2009). Winner of MES and the World Bank "Technology Commercialization" project (2011).

Research directionsCore publicationsInnovative developmentsServices
  • Development of test kits for the diagnosis of socially significant human diseases;
  • Investigation of genetic predisposition to multifactorial human diseases (breast cancer, cardiovascular diseases, metabolic diseases);
  • Development of highly-effective test kits for diagnosis of infectious animal diseases;
  • Genotyping of bacteria and viruses;
  • Epidemiological and epizootological monitoring of functional characteristics and variability of genomes of human and animal infectious diseases.
 
  • Akhmetova A., Kozhamkulov U., Bismilda V.

    Mutations in the pncA and rpsA genes among 77 Mycobacterium tuberculosis isolates in Kazakhstan // Int J Tuberc Lung Dis.  2015. Vol. 19, № 2.  P. 179-184.

  • Zholdybayeva E.V., Rakhimova S.E., Baikara B.T.

    Alport syndrome in a Kazakh family: a case study // J Genet.  2014.  Vol. 93, № 3.  P. 855-858.

  • Kulmambetova G.N., Imanbekova M.K., Logvinenko A.A.

    Association of cytokine gene polymorphisms with gastritis in a kazakh population // Asian Pac J Cancer Prev.  2014.  Vol. 15, № 18. P. 7763-7768.

  • Iskakova A., Romanova Voronina A., Voronina E.

    Allele Frequency and Genotype Distribution of 9 SNPs in the Kazakh Population // J Pharmacogenomics Pharmacoproteomics.  2014. Vol. 5, № 129.  P. 2153-0645.1000129.

  • Ibrayeva A., Kozhamkulov U., Raiymbek D.

    Molecular epidemiology of Mycobacterium tuberculosis strains circulating in the penitentiary system of Kazakhstan // Int J Tuberc Lung Dis.  2014.  Vol. 18, № 3.  P. 298-301.

  • Kuranov A.B., Vavilov M.N., Abildinova G.

    Polymorphisms of HLA-DRB1, -DQA1 and -DQB1 in inhabitants of Astana, the capital city of Kazakhstan // PLoS One.  2014.  Vol. 9, № 12.  P. e115265.

  • Kuranov A.B., Kozhamkulov U.A., Vavilov M.N.

    HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan // Tissue Antigens.  2014.  Vol. 83, № 2.  P. 106-112.

  • Dmitriev P., Kairov U., Robert T.

    Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes // J Cell Mol Med. 2014.  Vol. 18, № 2.  P. 208-217.

  • Tarlykov P.V., Zholdybayeva E.V., Akilzhanova A.R.

    Mitochondrial and Y-chromosomal profile of the Kazakh population from East Kazakhstan // Croat Med J.  2013.  Vol. 54, № 1.  P. 17-24.

  • Shoaib M., Kulyyassov A., Robin C.

    PUB-NChIP—“in vivo biotinylation” approach to study chromatin in proximity to a protein of interest // Genome Research.  2013. Vol. 23, № 2.  P. 331-340.

  • Shevtsov A., Tarlykov P., Zholdybayeva E.

    Draft Genome Sequence of the Live Vaccine Strain Brucella abortus 82 // Genome Announc.  2013.  Vol. 1, № 6.

  • Shevtsov A., Tarlykov P., Zholdybayeva E.

    Draft Genome Sequence of Rhodococcus erythropolis DN1, a Crude Oil Biodegrader // Genome Announc.  2013.  Vol. 1, № 5.

  • Akilzhanova A., Nurkina Z., Momynaliev K.

    Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer // Anticancer Res.  2013.  Vol. 33, № 9.  P. 4049-4059.

  • A kit for identification of histocompatibility complex based on DNA sequencing methods for use in clinical transplantology;
  • Diagnostic panel for estimation of individual drug dosage that reduces the risk of thrombosis;
  • Prototypes of real time PCR test kits for diagnosis of hepatitis B, C and G, Epstein-Barr virus, polyomavirus, cytomegalovirus; genotyping of human papilloma virus of high oncogenic risk;
  • A kit for comprehensive assessment of human predisposition to the development of gastritis, ulcer and stomach cancer based on the identification of virulence factors of Helicobacter pylori and mutation of interleukin-1 beta encoding gene.
  • Isolation of DNA, RNA;
  • DNA sequencing;
  • PCR analysis (Standard and Real time);
  • Screening for predisposition to diseases;
  • Creation of a genetic passports;
  • Identification of microorganisms;
  • HLA typing;
  • Genotyping of microorganisms, plants, animals;
  • On-site training seminars.

About us

Republican State Enterprise “National Center for Biotechnology” under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan (hereinafter – NCB) - country’s leading biological center,  implementing the State policy on support and development of biotechnology industry – was founded by the Decree of the President of the Republic of Kazakhstan in 1993. The center implements and coordinates the government-funded scientific – technical programmes in the field of biotechnology, biosafety and ecology.

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