Laboratory of Microorganisms Genetics and Biochemistry

Head of the Laboratory



Candidate of Chemistry Sciences 


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+7(7172) 70 75 22


Mr Khassenov specializes in the field of molecular genetics of microorganisms, protein mass-spectrometry and proteomics, recombinant DNA technology. He is an author of more than 30 scientific works, has 3 Author’s Certificates on recombinant strains of microorganisms producing protein with enzymic and antigenic specificity. In 2000 was acknowledged by the Ministry of Education and Science of Kazakhstan for contribution to development of education system of the Republic of Kazakhstan and in 2003 – by National Academy of Science (NAS) of the Republic of Kazakhstan for active participation in NAS activities. Researcher at the laboratory of DNA repair, L’Institut Gustave Roussy, CNRS (France, 2007-2009).

Research directionsCore publicationsInnovative developmentsServices
  • Development of genetically engineered schemes for end production processing: proteins, recombinant microorganisms, transgenic plants;
  • Development of processing technology for transgenic plants expressing medical-use genes;
  • Derivation of recombinant proteins with enzymic and antigenic specificity in bacteria and yeasts;
  • Studying the mechanisms for DNA repair in prokaryotic and eukaryotic organisms.
  • А.В. Шустов, С.З. Ескендирова, Е. Манат, Г.Б. Унышева, Н.И. Сарина

    Получение рекомбинантного антигена бруцелл - Cu/Zn-зависимой супероксиддисмутазы (SOD). Биотехнология. Теория и практика. - 2013. - №3.- С.65-70.

  • А.С. Камзина, А.Ж. Балтабекова, А.В. Шустов

    Эффективный метод получения вирусоподобных частиц, несущих эпитопы иммуноглобулина человека. Биотехнология. Теория и практика. - 2013. - №3.- С.20-25.

  • А.Е. Секенова, М.Ж. Балтабекова, Б.Б. Хасенов, В.Б. Огай

    Получение и анализ поликлональных антител к рекомбинантному транскрипционному  фактору Sox 2. Биотехнология. Теория и практика. – 2013.- №1.- С.16-19.

  • Z. Berdygulova, D. Esyunina, N. Miropolskaya, D. Mukhamedyarov, K. Kuznedelov, B. Nickels, K.  Severinov, A. Kulbachinskiy, L. Minakhin 

    A novel phage-encoded transcription antiterminator acts by suppressing bacterial RNA polymerase pausing. Nucleic Acids Res. 2012 May 1;40 (9):4052-63. 8.026.

  • Д.Г. Ахметова, Ж.А. Бердыгулова, Е.Б. Евтыхова, А.В. Шустов

    Сальмонеллы: молекулярные механизмы приспособленности и факторы вирулентности. Биотехнология. Теория и практика.-.2012.-.№1.-.С.3-24.

  • Z. Berdygulova, L.F. Westblade, L. Florens, E.V. Koonin, B.T. Chait, E.М. Ramanсulov, M.P. Washburn, S.A. Darst, K. Severinov, L. Minakhin

    Temporal Regulation of Gene Expression of the Thermus thermophilus Bacteriophage. J. Mol. Biol. 2011, Jan 7;405(1):125-42.

  • Genetic design and strain, producing protein of p.24 leukemia virus in cattle in a bacterial culture;
  • Highly active taq-pol recombinant polymerase.
  • Trivial identification of microorganisms through genotyping;
  • Development  of genetic designs for different purposes;
  • Production of recombinant protein in prokaryote system.

About us

Republican State Enterprise “National Center for Biotechnology” under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan (hereinafter – NCB) - country’s leading biological center,  implementing the State policy on support and development of biotechnology industry – was founded by the Decree of the President of the Republic of Kazakhstan in 1993. The center implements and coordinates the government-funded scientific – technical programmes in the field of biotechnology, biosafety and ecology.

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