Laboratory of Immunochemistry and Immunobiotechnology

Head of the laboratory

 

KANATBEK MUKANTAYEV

 
Doctor of Biological Sciences, Associated Professor 

 

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+7(7172) 70 75 27

 
 

Specialist in the fields of hybridoma technology and development of test system based on monoclonal antibody, author of more than 100 scientific articles, holds 15 patents of hybridoma strains that produce monoclonal antibody and microorganism strains that produce recombinant antigens. He was awarded the badge “For contribution in development of science of the Republic of Kazakhstan” in 2011.

Research directionCore publicationsInnovative developmentsServices
  • Development of test-systems for diagnosis of infectious diseases in animals and human (including extremely dangerous) on the basis of monoclonal antibodies and recombinant antigens;
  • Development of immunochromatographic test-system for potato viral infection on the basis of monoclonal antibody;
  • Obtaining and production of viral recombinant antigens;
  • Obtaining monoclonal antibody for tumor-associated antigens on the surface of plasmic membrane of tumor cells (breast cancer).
 
  • Мукантаев К.Н., Байдосова Ш., Шустов А.В., Турсунов К., Муканов К.К.

    Получение рекомбинантного антигена VP1 вируса ящура серотипа О и Азия-1. Биотехнология. Теория и практика. – 2012. - 3. – С.65-71

  • Мукантаев К.Н., Шустов А.В., Сыдыкнаби Ы., Бегалиева А., Райымбек Г., Муканов К.К.

    Получение рекомбинантного белкового фрагмента gp51 антигена вируса лейкоза крупного рогатого скота, экспрессированного в E.coli без тиоредоксиновой вставки. Биотехнология. Теория и практика. – 2014. - 1. – С.49-57

  • Мукантаев К.Н., Шустов А.В., Сыдыкнаби Ы., Інірбай Б.,Бегалиева А., Муканов К.К

    Иммуноферментный анализ на основе рекомбинантного VP1 антигена для серологической диагностики ящура. Биотехнология. Теория и практика. – 2014. - 2. – С.36-41

  • Ескендирова С.З., Унышева Г.Б., Муканов К.К. и др.

    Инновационный патент РК №21863 «Штамм гибридных культивируемых клеток животных Mus musculus L. «МАВ/MCF-3Д4» - продуцент моноклональных антител к белковому антигену опухолевых клеток аденокарциномы молочной железы MCF-7, используемый в качестве диагностического реагента для мониторинга онкозаболевания»

  • Ескендирова С.З., Бызова Н.А., Жердев А.В, Дзантиев Б.Б. 

    Разработка иммунохроматографической тест-системы для экспрессной детекции липополисахаридного антигена и интактных клеток возбудителя бруцеллеза крупного рогатого скота. Прикладная биохимия и микробиология.- 2012, т. 48, № 6, с. 653–661

  • Eskendirova S.Z., Sotnicov D.V., Byzova N.A. 

    Development and validation of immunochromatographic test-systems for thediagnosis of bovine brucellosis. Journal of Veterinary Diagnostic Investigation.- 2013.-P. 25-42.

  • Enzym linked imunnosurbent assay based on recombinant non-structural antigen of foot-and-mouth disease virus for differential diagnostics of vaccinated animals from infected ones;
  • Immunofluorescent and Enzym linked imunnosurbent assay methods on the basis of monoclonal antibodies and recombinant antigens of cattle’s leucosis virus;
  • Enzym linked imunnosurbent assay for serologic diagnosis of lues venereal on the basis of recombinant antigens;
  • Enzym linked imunnosurbent assay for serologic diagnosis of foot-and-mouth disease on the basis of monoclonal antibody and recombinant antigens in cattle;
  • Enzym linked imunnosurbent assay based on monoclonal antibodies for serologic diagnosis of foot-and-mouth disease in cattle;
  • Enzym linked imunnosurbent assay based on monoclonal antibodies and recombinant antigens for serologic diagnosis of rabies in livestock;
  • Immunochromatographic assay for serologic diagnostics of Brucella abortis in cattle;
  • Immunochromatographic test analysis for serological diagnosis of foot-and-mouth disease based on recombinant VP1 antigen of O, A, and Asia serotypes;
  • Immunochromatographic test analysis of potato virus detection based on monoclonal antibody;
  • Immunochromatographic test analysis for serological diagnosis of leucosis in cattle based on recombinant р24 and gp51 antigens.
  • Development of monoclonal antibodies to different biologically active moleculs;
  • Development of polyclonal antibodies to different biologically active moleculs;
  • Development of second antibodies conjugated with peroxidases;
  • Development of second antibodies conjugated with FITS.

About us

Republican State Enterprise “National Center for Biotechnology” under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan (hereinafter – NCB) - country’s leading biological center,  implementing the State policy on support and development of biotechnology industry – was founded by the Decree of the President of the Republic of Kazakhstan in 1993. The center implements and coordinates the government-funded scientific – technical programmes in the field of biotechnology, biosafety and ecology.

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