Synthesis and structure of novel ylidene derivatives of methanobenzo[g]thiazolo[2,3-d][1,3,5]oxadiazocine

Chem Heterocycl Comp (2016) 52: 331
Ivan V. Kulakov, Diana N. Ogurtsova, Zarina T. Shulgau, Tulegen M. Seilkhanov, Yurii V. Gatilov
First Online: 01 July 2016
DOI: 10.1007/s10593-016-1886-7

Abstract:

Novel benzylidene and furylidene derivatives of tricyclic thiazolo[2,3-d][1,3,5]oxadiazocines were synthesized, and their structures were confirmed by 1H and 13C NMR spectroscopy. It was shown that ylidene derivatives of 11H-5,11,5-pentane-[1,1,5]triyl[1,3]thiazolo[2,3-d]-[1,3,5]oxadiazocin-1-one are obtained as a mixture of Z- and E-isomers. Recrystallization of the isomer mixture affords the major Z-isomer, structure of which has been established by X-ray structural analysis.

Keywords: diastereomers methanobenzo[g]thiazolo[2,3-d][1,3,5]oxadiazocines ylidenes antidiabetic activity NMR spectroscopy X-ray structural analysis

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Republican State Enterprise “National Center for Biotechnology” under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan (hereinafter – NCB) - country’s leading biological center,  implementing the State policy on support and development of biotechnology industry – was founded by the Decree of the President of the Republic of Kazakhstan in 1993. The center implements and coordinates the government-funded scientific – technical programmes in the field of biotechnology, biosafety and ecology.

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